The year 1601 CE in science and technology included many events, some of which are listed below.

Computer science January 1 – Retrospectively the epoch reference date from which ANSI dates are counted in COBOL and other computer languages, and the base of Windows FILETIME timestamps which are stored as a 63 bit counter, whose last valid timestamp is on 14 September, AD 30828 at 02:48:05.4775807 UTC.

Exploration August 26 – Olivier van Noort completes his circumnavigation of the world.

Mathematics Johannes Kepler is appointed imperial mathematician to the Habsburg Empire.

Physiology and medicine Giulio Cesare Casseri publishes a treatise on the anatomy of the vocal and auditory organs in Ferrara.

Births possible date – Edward Somerset, 2nd Marquess of Worcester, English inventor (d. 1667)

Deaths October 24 – Tycho Brahe, Danish astronomer (b. 1546)

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