Marie-Claude is a French feminine compound given name. Notable people with the name include:
Marie-Claude Arnaud, French mathematician Marie-Claude Asselin, Canadian freestyle skier Marie-Claude Audet (born 1962), Canadian cyclist Marie-Claude Beaud (1946–2024), French museumist Marie-Claude Beaudeau (born 1937), French politician Marie-Claude Bibeau (born 1970), Canadian politician Marie-Claude Bierre, French figure skater Marie-Claude Blais, Canadian politician Marie-Claude Bomsel (born 1946), French veterinarian Marie-Claude Bourbonnais (born 1979), Canadian model Marie-Claude Bouthillier, Canadian artist Marie-Claude Chappuis (born 1969), Swiss operatic mezzo-soprano Marie-Claude Deslières (born 1966), Canadian water polo player Marie-Claude Dion (born 1974), Canadian soccer player Marie-Claude Doyon (born 1965), Canadian luger Marie-Claude Gaudel, French mathematician and computer scientist Marie-Claude Guigue (1832–1889), French historian Marie-Claude Mattéi-Müller, French-Venezuelan anthropologist and ethnolinguist Marie-Claude Molnar (born 1983), Canadian para-cyclist Marie-Claude Monchaux (1933–2021), French children's book writer and illustrator Marie-Claude Morin (born 1985), Canadian politician Marie Claude Naddaf, Syrian activist Marie-Claude Najm (born 1971), Lebanese academic and politician Marie-Claude Nichols (born 1973), Canadian politician Marie-Claude Pietragalla (born 1963), French dancer and choreographer Marie-Claude Sandrin (born 1937), French writer Marie-Claude Savard-Gagnon (born 1972), Canadian pair skater Marie-Claude Tjibaou (born 1949), New Caledonian activist and politician Marie-Claude Treilhou (born 1948), French film director Marie-Claude Vaillant-Couturier (1912–1996), World War II French Resistance member, photojournalist and communist politician Marie-Claude Vayssade (1936–2020), French politician