O'Dwyer or O'Dwyers may refer to:
House of (Clan) O'Dwyer
People O'Dwyer (surname) O'Dwyers of Kilnamanagh William O'Dwyer, 100th mayor of New York City (1946–1950) Sinéad O'Dwyer (born ), Irish fashion designer
Other J. R. O'Dwyer Company, magazine publisher for the United States public relations industry O'Dwyers GAA, a Gaelic Athletic Association club based at Hamlet Lane, Balbriggan, County Dublin, Ireland O'Dwyer VLe, handgun – see List of caseless firearms
See also Dwyer (disambiguation) Dwyre