Channel 21, or TV 21 or TV21 may refer to:

Channel 21, a defunct German television channel TV 21, a television channel in North Macedonia Canal 21, the former name of Tunisian television channel El Watania 2 L'Équipe 21, a television channel in France ETC-21, a television station in Quezon City, Philippines Canal Orbe 21, a television station in Buenos Aires, Argentina; formerly known as Canal 21 Citytv Bogota, a television station in Bogota, Colombia Enlace Nicaragua, a Christian television station in Nicaragua Rede 21, a defunct Brazilian television network RTL9, a Luxembourgish French-language channel, formerly known as Canal 21 in France Télé 21, the former name of Belgian-French television channel Tipik Antena 21, a Dominican television channel Canal 21 (El Salvador), a Salvadoran television channel

Canada CHNU-DT-1, virtual channel 21 in Victoria, British Columbia CJON-DT, virtual channel 21 in St. John's, Newfoundland and Labrador

Mexico XHTIT-TDT, virtual channel 21, carries Azteca 7 in Tijuana, Baja California XHCDM-TDT, virtual channel 21 in Mexico City

UHF frequencies covering 512-518 MHz Channel 21 TV stations in Canada Channel 21 TV stations in Mexico Channel 21 digital TV stations in the United States Channel 21 low-power TV stations in the United States

Other uses TV21, an early 1980s British new wave band TV Century 21, a weekly British children's comic published during the 1960s

See also 21 (disambiguation) Channel 21 branded TV stations in the United States Channel 21 virtual TV stations in the United States