5-MeS-DMT, also known as 5-methylthio-N,N-dimethyltryptamine or as 5-methylthio-DMT, is a lesser-known psychedelic drug of the tryptamine family. It is the 5-methylthio derivative of dimethyltryptamine (DMT) and is an analogue of 5-MeO-DMT.
Use and effects In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin lists the dose as 15 to 30mg smoked and its duration as less than 1hour. In individual reports, the duration was 10 to 30minutes. The effects included feeling stoned and no visuals, among others. It was also described as coming on very fast and being quite intense. The drug is said to be about half as potent as 5-MeO-DMT.
Interactions
Pharmacology Pharmacodynamics 5-MeS-DMT was less potent than 5-MeO-DMT and psilocin (4-HO-DMT) but more potent than 4-MeO-DMT or 4-MeS-DMT in rodent behavioral studies. It is known produce generalization with 5-MeO-DMT in rodent drug discrimination tests, with only slightly lower potency in comparison.
Chemistry Synthesis The chemical synthesis of 5-MeS-DMT has been described.
Analogues Analogues of 5-MeS-DMT include dimethyltryptamine (DMT), 5-MeO-DMT, 5,N,N-TMT (5-methyl-DMT; 5-Me-DMT), HBL20016 (5-MeS-6-F-DMT), and HBL20017 (4-F-5-MeS-DMT), among others.
History It was first described in the scientific literature by Richard Glennon and colleagues by 1982. However, 5-MeS-DMT was synthesized and tested by Shulgin as early as 1979.
See also Substituted tryptamine
References
External links 5-MeS-DMT - Isomer Design 5-MeS-DMT - TiHKAL - Erowid 5-MeS-DMT - TiHKAL - Isomer Design