USS O'Toole has been the name of more than one United States Navy ship, and may refer to:
USS O'Toole (DE-274), a destroyer escort transferred to the United Kingdom upon completion which served in the Royal Navy as from 1943 to 1945 USS O'Toole (DE-327), a destroyer escort renamed in 1943 while under construction , a destroyer escort in commission from 1944 to 1945