Sclerosis (also sclerosus in the Latin names of a few disorders) is a hardening of tissue and other anatomical features. It may refer to:

Sclerosis (medicine), a hardening of tissue in zoology, a process, sclerotization, which forms sclerites, a hardened exoskeleton in botany, a process which hardens plant tissue by adding fibers and sclereids, resulting in sclerenchyma in economics, eurosclerosis

ar:تَصلُب ca:Esclerosi mk:Склероза pl:Stwardnienie fi:Skleroosi sv:Skleros zh:硬化