Second Presbyterian Church may refer to:
Northern Ireland
Second Ballyeaston Presbyterian Church, a congregation of the Presbyterian Church in Ireland United States
Second Presbyterian Church (Guilford, Baltimore, Maryland), church of Franklin L. Sheppard Second Presbyterian Church (Birmingham, Alabama), listed on the NRHP in Alabama Second Presbyterian Church (Chicago, Illinois), listed on the NRHP in Illinois Second Presbyterian Church (Indianapolis, Indiana) Second Presbyterian Church (Lexington, Kentucky), listed on the NRHP in Kentucky Second Presbyterian Church (St. Louis, Missouri), listed on the NRHP in Missouri Second Presbyterian Church (Princeton, New Jersey), merged with Nassau Presbyterian Church Second Presbyterian Church (Columbus, Ohio), listed on the NRHP in Ohio Second Presbyterian Church (Portsmouth, Ohio), listed on the NRHP in Ohio Second Presbyterian Church (Chattanooga, Tennessee), listed on the NRHP in Tennessee Second Presbyterian Church (Memphis, Tennessee) (1891), listed on the NRHP in Tennessee Second Presbyterian Church (Memphis, Tennessee) (1952) Second Presbyterian Church (Petersburg, Virginia), listed on the NRHP in Virginia Second Presbyterian Church (Richmond, Virginia), listed on the NRHP in Virginia