William Houston (c. 1746–1788) was one of the Founding Fathers of the United States.

William Houston may also refer to:

Sir William Houston, 1st Baronet (1766–1842), Governor of Gibraltar William Houston (actor) (born 1968), British actor William Houstoun (botanist) (1695–1733), Scottish surgeon and botanist William C. Houston (1852–1931), American politician and U.S. Representative from Tennessee William J. Houston (born 1968), American Navy officer William V. Houston (1900–1968), American physicist Will Houston (rugby union) (born 1988), Australian professional rugby union referee Bill Houston (American football) (born 1951), American football wide receiver Bill Houston (Australian footballer) (1918–1982), Australian rules footballer Bill Houston, singer/songwriter, see North of Superior See also William Houstoun (disambiguation)