Santini is an Italian surname. Notable people with the surname include:
André Santini (1940–2026), French politician Bob Santini (born 1932), American basketball player Brandon Santini (born 1982), American blues harmonica player, singer and songwriter Chay Santini, Puerto Rican fashion model and actress Claudio Santini (born 1992), Italian football player Dalmazio Santini (1923–2001), Italian-born U.S. composer Daniele Santini (born 1992), Italian sprint canoeist Didier Santini (born 1968), French football player Edna Santini (born 1992), Brazilian rugby sevens player Fortunato Santini (1777–1861), Italian priest, composer and music collector Gabriel Santini (born 2000), Italian footballer Gabriele Santini (1886–1964), Italian conductor Giovanni Sante Gaspero Santini (1787–1877), Italian astronomer and mathematician Graziella Santini (born 1960), Sammarinese athlete Giuseppe Santini (1735–1796), Italian abbot and a mathematician Inti Muñoz Santini (born 1974), Mexican politician Ivan Santini (born 1989), Croatian footballer Jacques Santini, French footballer James David Santini (1937–2015), United States Representative from Nevada Jan Santini Aichel (1677–1723), Czech baroque architect of Italian descent Jorge Santini, Puerto Rican politician, former mayor of San Juan Krševan Santini (born 1987), Croatian football goalkeeper Nadia Santini, Italian chef Nilmaris Santini (1959–2006), Puerto Rican female judoka Norma Santini (born 1932), Venezuelan fencer Rinaldo Santini (1914–2013), Italian Christian Democrat politician Ruggiero Santini (1870–1958), Italian general Steven Santini (born 1995), American ice hockey defenseman Seven Santini Brothers, founders of the eponymous moving and storage company Wellentony Tafua Santini (born 1993), Australian rugby league footballer
Fictional characters Dominic Santini, a character in the television series Airwolf Carla Santini, a character in the film/book Confessions of a Teenage Drama Queen
See also 37699 Santini-Aichl, a minor planet discovered 4158 Santini, a minor planet Santini SMS, Italian cycling clothes brand Santini-Conti, professional continental cycling team registered in Italy Seven Santini Brothers, full-service American moving, storage, and relocation company The Great Santini (novel), written by Pat Conroy and published in 1976 Santino, a male given name Santos (disambiguation) Satini, a given name and surname