Lorenzo de' Medici (1449–1492), or Lorenzo the Magnificent, was an Italian statesman, banker, de facto ruler of the Florentine Republic and patron of Renaissance culture.

Lorenzo de' Medici may also refer to:

People Lorenzo the Elder (1395–1440) Lorenzo di Pierfrancesco de' Medici (1463–1503) Lorenzo de' Medici, Duke of Urbino (1492–1519) Lorenzino de' Medici (1514–1548), or Lorenzaccio Lorenzo de' Medici (1599–1648), seventh child of Ferdinando I de' Medici, Grand Duke of Tuscany

Other uses Lorenzo de' Medici School, in Florence, Italy

See also Lorenzo De Medici Sweat (1818–1898), an American politician Lorenzaccio, an 1834 play by Alfred de Musset Lorenzaccio (film), 1951 Lorenzaccio (horse) (1965–1983)