William or Willie Burke may refer to:
Law and politics William J. Burke (1862–1925), American politician and businessman William H. Burke Jr. (1906–1975), American political figure W. Lewis Burke (born 1948; born William Lewis Burke) American lawyer and law professor William Burke-White, American law professor and policy advisor
Sports William Burke (baseball) (1865–1939), American baseball player William H. Burke (fl. 1899–1906), American football coach Willie Burke (born 1972), Irish footballer
Others William mac Ulick Burke, 4th Clanricarde or Mac William Uachtar (d. 1430), Irish chieftain and noble William Burke, Lord of Bealatury (fl. 1580s-1616), Irish noble and soldier William Burke (prior) (c. 1611–c. 1685), Irish Dominican cleric William Burke, 7th Earl of Clanricarde (died 1687), Irish peer William Burke (pirate) (died 1699), Irish pirate William Burke (author) (1729–1798), English pamphleteer William Burke (Burke and Hare murders) (1792–1829), Irish-Scots serial killer William Malachy Burke (1819–1879), Irish physician and Registrar General William Burke Miller (1904–1983), American newspaper and radio reporter William L. Burke (1941–1996), American astronomy, astrophysics, and physics professor
See also Billy Burke (disambiguation) William de Burgh (disambiguation), once used interchangeably with Burke William Burgh (disambiguation), once used interchangeably with Burke