Gainsborough or Gainsboro may refer to:

Places Gainsborough, Ipswich, Suffolk, England Gainsborough Ward, Ipswich Gainsborough, Lincolnshire, a town in England Gainsborough (UK Parliament constituency) Gainsborough, Saskatchewan, Canada Gainsboro, Roanoke, Virginia Gainesboro, Tennessee Gainesboro, Virginia

People Earl of Gainsborough, a title in the peerage of England and the peerage of the United Kingdom Humphrey Gainsborough (1718–1776), English minister and engineer Thomas Gainsborough (1727–1788), English painter William Gainsborough (died 1307), Bishop of Winchester

Other Aerith Gainsborough, a fictional character from Final Fantasy VII Gainsborough (crater), on the planet Mercury Gainsborough (horse), the 1918 Triple Crown Champion of English Thoroughbred Racing HMS Gainsborough, two ships of the Royal Navy Gainsborough Pictures, a London-based film studio, active between 1924 and 1951 Gainsborough melodramas, a group of films made by the studio Gainsborough chair, a type of chair made in 18th century England Gainsborough hat, a hat in the style of those in Thomas Gainsborough's paintings Gainsboro, a color in the X11 color scheme a mullein (plants in the genus Verbascum) cultivar