Gene Smith may refer to:
Gene Smith (American football executive) (born 1963), former general manager for the Jacksonville Jaguars Gene Smith (American football coach) (died 1987), former college football coach Gene Smith (American football guard) (1905–1979), American football guard Gene Smith (athletic director), athletic director at The Ohio State University Gene Smith (baseball) (1911–1995), Negro league baseball player Gene A. Smith (born 1963), American historian E. Gene Smith (1936–2010), scholar of Tibetology Ray Gene Smith (1928–2005), American football player
See also Eugene Smith (disambiguation)