SB2 may refer to:

.sb2 file, a file format for Scratch Antimonide S3 (classification), or SB2, a disability swimming classification for breastroke Scratchbox 2, a cross-compilation toolkit for Linux Surface Book 2, a Microsoft computer Tupolev SB, a Russian 1930s bomber a form of Methanobactin produced by Methylocystis bacteria a type of spectroscopic binary star a series of Bimota motorcycles by Suzuki an upgrade of the Smart Roadster

See also Brewster SB2A Buccaneer, an American 1940s dive bomber Curtiss SB2C Helldiver, an American 1940s dive bomber Vought SB2U Vindicator, an American 1930s dive bomber SB20, a class of sailboat