Samuel Cook may refer to:

Samuel Cook (artist) (1806–1859), English watercolour painter Samuel Cook (Chartist) (1786–1861) Samuel A. Cook (1849–1918), U.S. representative from Wisconsin Samuel Albert Cook (1878–1915), medical doctor and member of the American Red Cross mission in Serbia Sam C. Cook (1855–1924), Mississippi Supreme Court justice Samuel DuBois Cook (1928–2017), political scientist and professor Samuel E. Cook (1860–1946), U.S. representative from Indiana Samuel Edward Cook (1787–1856), English writer Samuel Edward-Cook (born 1990), English actor Samuel H. Cook, United States Army officer of the Civil War J. Samuel Cook (born 1983), African-American playwright, journalist and writer

See also Sam Cook (disambiguation) Samuel Cooke (disambiguation) Cook (surname)