Talkalakh District () is a district of the Homs Governorate in central Syria. Administrative centre is the city of Talkalakh. At the 2004 census, the district had a population of 129,429.

Sub-districts The district of Talkalakh is divided into four sub-districts or nawāḥī (population as of 2004): Talkalakh Subdistrict (ناحية تلكلخ): population 62,069. Hadidah Subdistrict (ناحية حديدة): population 25,998. Al-Nasirah Subdistrict (ناحية الناصرة): population 16,678. Al-Hawash Subdistrict (ناحية الحواش): population 24,684.

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