Francis or Frank Duffy may refer to:
Francis Duffy (bishop) (born 1958), Roman Catholic Bishop of Ardagh and Clonmacnoise Francis Clyde Duffy (1890–1977), Lieutenant Governor of North Dakota Francis Noel Duffy (born 1971), Irish Green Party politician for Dublin South-West Francis P. Duffy (1871–1932), Roman Catholic priest in the U.S. Frank Duffy (architect) (1940–2026), British architect Frank Duffy (baseball) (born 1946), Major League Baseball player Frank Duffy (curler) (1959–2010), Scottish wheelchair curler Frank Duffy (equestrian) (born 1937), American equestrian Frank Duffy (labor leader) (1861–1955), American labor leader and secretary-general Sir Frank Gavan Duffy (1852–1936), Australian judge
See also F. Ryan Duffy (1888–1979), U.S. Senator from Wisconsin