Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.
Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Interactions
HDAC1 has been shown to interact with:
Androgen receptor, BCL6, BTG2, BUB1B, BUB1, BUB3, CBFA2T3, CDC20, CDH1, CHD3, CHD4, COUP-TFII, CTBP1, DDX17, DDX5, DNMT3A, DNMT3L, Death-associated protein 6, EED, EVI1, EZH2, FKBP3, GATA1, HMG20B, HSPA4, HUS1, Histone deacetylase 2, Homeobox protein TGIF1, Host cell factor C1, IFRD1, IKZF1, ING1, MBD3, MIER1, MLL, MTA1, MTA2, Mad1, Mdm2, Methyl-CpG-binding domain protein 2, Mothers against decapentaplegic homolog 2, MyoD, NFKB1, Nuclear receptor co-repressor 2, P21, PCNA, PHF21A, Prohibitin, Promyelocytic leukemia protein, RAD9A, RBBP4, RBBP7, RCOR1, RELA, RFC1, Retinoblastoma protein, Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, SAP30, SATB1, SIN3A, SIN3B, SPEN, SUDS3, SUV39H1, Sp1 transcription factor, TOP2A, TOP2B, and Zinc finger and BTB domain-containing protein 16.
See also Histone deacetylase Histone deacetylase inhibitor
References
Further reading
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