Powerball is a multi-state lottery game in the United States.
Powerball may also refer to:
Lotteries Powerball (Australia), a lottery operated in Australia The Powerball game of Lotto New Zealand The PowerBall game in the South African National Lottery
Arts, entertainment, and media Powerball (video game), a game for the Sega Genesis Powerball, an event on the sports competition show American Gladiators Powerball, a mode in the strategy shooting game GunBound Powerballin', a 2004 Chingy album
Other uses Powerball, a brand of gyroscopic exercise tool Powerballing, alternate name for the drug speedball