Cottonwood River may refer to one of four rivers in North America:
Cottonwood River (Kansas), a tributary of the Neosho River Cottonwood River (Minnesota), a tributary of the Minnesota River Cottonwood River (Dease River tributary), originating in the northern Stikine Ranges of British Columbia Cottonwood River (Fraser River tributary), originating in Cariboo District, British Columbia, Canada Little Cottonwood River, a tributary of the Minnesota River
See also Cottonwood (disambiguation)