Vitamin B is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.

B12 or B-12 may also refer to:

Music B12 (band), a British electronic music duo "B12", a song by Grey Daze led by Chester Bennington "B12", a song by Lil Durk from Almost Healed

Transportation B12 (New York City bus), a bus line serving Brooklyn Bensen B-12, a 1961 American unconventional multirotor helicopter Chery B12, a 2007 Chinese Chery automobile model LNER Class B12, a class of steam locomotives Mallee Highway or B12, in Australia Martin B-12, a modified version of the Martin B-10 bomber Nissan Sunny B12, a car model Queensland B12 class locomotive, a class of steam railway locomotive Alpina B12, a car model by Alpina

Other uses Brandon C. Rodegeb or B-12 (born 1977), American music executive, film-maker, rap artist, and writer Caro–Kann Defence's ECO code in chess B12, a student model clarinet manufactured by Buffet Crampon Amorphous boron, B12, icosahedral allotrope of boron Boron-12 (B-12 or 12B), a short-lived isotope of boron Big 12 Conference

See also HLA-B12, an HLA-B serotype IgG1-b12, an antibody against the HIV surface protein gp120 found in some long-term nonprogressors 12B (disambiguation)