Little Poison may refer to:
Bruce Mather (ice hockey) (1926–1975), an American ice hockey player Jesús Pimentel (born 1940), a Mexican bantamweight boxer Rigoberto Riasco (1953–2022), a Panamanian professional boxer Paul Runyan (1908–2002), American professional golfer Lloyd Waner (1906–1982), Major League Baseball center fielder with the Pittsburgh Pirates Lil Poison, born Victor De Leon III (1998), the youngest professional gamer