The 2000 Arizona Diamondbacks season was the franchise's 3rd season in Major League Baseball and their 3rd season at Bank One Ballpark in Phoenix, Arizona, as members of the National League West.

They looked to improve on their 1999 season, in which they won 100 games in just their second season. They looked to contend in what was a strong National League West. They finished the season with a record of 85–77, good enough for third place in the division.

Offseason November 15, 1999: Ken Huckaby was signed as a free agent with the Arizona Diamondbacks. November 22, 1999: Ernie Young was released by the Arizona Diamondbacks. December 15, 1999: Dante Powell was traded by the Arizona Diamondbacks to the St. Louis Cardinals for Luis Ordaz. March 20, 2000: Craig Counsell was signed as a free agent with the Arizona Diamondbacks.

Regular season Randy Johnson tied a modern record with six victories in April 2000. He would lead the league in strikeouts with 347 and in winning percentage (.731). Johnson won his third Cy Young Award, and became the third National League pitcher to win the trophy in consecutive seasons. Johnson recorded his 3000th strikeout on September 10, 2000, as he whiffed Florida Marlins' third baseman Mike Lowell.

Opening Day starters Jay Bell Erubiel Durazo Steve Finley Luis Gonzalez Lenny Harris Randy Johnson Travis Lee Damian Miller Tony Womack

Notable transactions June 2, 2000: Bill Pulsipher was traded by the New York Mets to the Arizona Diamondbacks for Lenny Harris. June 5, 2000: Brandon Webb was drafted by the Arizona Diamondbacks in the 8th round of the 2000 amateur draft. Player signed June 6, 2000. July 26, 2000: Curt Schilling was traded by the Philadelphia Phillies to the Arizona Diamondbacks for Omar Daal, Nelson Figueroa, Travis Lee, and Vicente Padilla.

Season standings

Record vs. opponents

Game log Legend Diamondbacks Win Diamondbacks Loss Game postponed

|- style="text-align:center; background:#bfb;" | 1 || April 4 || Phillies || 6–4 || Johnson || Ashby || Holmes (1) || Bank One Ballpark || 44,298 || 1–0 || Philadelphia Phillies at Arizona Diamondbacks Box Score, April 4, 2000 |- style="text-align:center; background:#bfb;" | 2 || April 5 || Phillies || 11–3 || Stottlemyre || Byrd || Morgan (1) || Bank One Ballpark || 29,291 || 2–0 || Philadelphia Phillies at Arizona Diamondbacks Box Score, April 5, 2000 |- style="text-align:center; background:#bfb;" | 3 || April 6 || Phillies || 3–2 (11) || Springer || Schrenk || None || Bank One Ballpark || 28,774 || 3–0 || Philadelphia Phillies at Arizona Diamondbacks Box Score, April 5, 2000 |- style="text-align:center; background:#fbb;" | 4 || April 7 || Pirates || 2–7 || Christiansen || Reynoso || None || Bank One Ballpark || 32,536 || 3–1 || Pittsburgh Pirates at Arizona Diamondbacks Box Score, April 7, 2000 |- style="text-align:center; background:#bfb;" | 5 || April 8 || Pirates || 6–5 || Swindell || Christiansen || None || Bank One Ballpark || 33,298 || 4–1 || Pittsburgh Pirates at Arizona Diamondbacks Box Score, April 8, 2000 |- style="text-align:center; background:#bfb;" | 6 || April 9 || Pirates || 1–0 || Johnson || Schmidt || None || Bank One Ballpark || 34,204 || 5–1 || Pittsburgh Pirates at Arizona Diamondbacks Box Score, April 9, 2000 |- style="text-align:center; background:#bfb;" | 7 || April 10 || @ Padres || 8–4 || Stottlemyre || Williams || Morgan (2) || Qualcomm Stadium || 60,021 || 6–1 || Arizona Diamondbacks at San Diego Padres Box Score, April 10, 2000 |- style="text-align:center; background:#fbb;" | 8 || April 11 || @ Padres || 2–3 (13) || Whisenant || Springer || None || Qualcomm Stadium || 19,035 || 6–2 || Arizona Diamondbacks at San Diego Padres Box Score, April 11, 2000 |- style="text-align:center; background:#fbb;" | 9 || April 12 || @ Padres || 2–4 || Meadows || Reynoso || Hoffman (1) || Qualcomm Stadium || 15,801 || 6–3 || Arizona Diamondbacks at San Diego Padres Box Score, April 12, 2000 |- style="text-align:center; background:#bfb;" | 10 || April 13 || @ Padres || 5–4 || Anderson || Hitchcock || Morgan (3) || Qualcomm Stadium || 28,131 || 7–3 || Arizona Diamondbacks at San Diego Padres Box Score, April 13, 2000 |- style="text-align:center; background:#bfb;" | 11 || April 14 || @ Giants || 3–1 || Johnson || Hernandez || None || Pacific Bell Park || 40,930 || 8–3 || Arizona Diamondbacks at San Francisco Giants Box Score, April 14, 2000 |- style="text-align:center; background:#bfb;" | 12 || April 15 || @ Giants || 7–4 || Stottlemyre || Ortiz || Swindell (1) || Pacific Bell Park || 40,930 || 9–3 || Arizona Diamondbacks at San Francisco Giants Box Score, April 15, 2000 |- style="text-align:center; background:#fbb;" | 13 || April 17 || Rockies || 1–9 || Yoshii || Daal || None || Bank One Ballpark || 33,743 || 9–4 || Colorado Rockies at Arizona Diamondbacks Box Score, April 17, 2000 |- style="text-align:center; background:#bfb;" | 14 || April 18 || Rockies || 7–1 || Reynoso || Karl || None || Bank One Ballpark || 30,275 || 10–4 || Colorado Rockies at Arizona Diamondbacks Box Score, April 18, 2000 |- style="text-align:center; background:#bfb;" | 15 || April 19 || Rockies || 8–7 || Morgan || Tavarez || Kim (1) || Bank One Ballpark || 31,237 || 11–4 || Colorado Rockies at Arizona Diamondbacks Box Score, April 19, 2000 |- style="text-align:center; background:#bfb;" | 16 || April 20 || Rockies || 3–0 || Johnson || Arrojo || None || Bank One Ballpark || 34,458 || 12–4 || Colorado Rockies at Arizona Diamondbacks Box Score, April 20, 2000 |- style="text-align:center; background:#fbb;" | 17 || April 21 || Giants || 5–11 || Ortiz || Stottlemyre || None || Bank One Ballpark || 40,929 || 12–5 || San Francisco Giants at Arizona Diamondbacks Box Score, April 21, 2000 |- style="text-align:center; background:#fbb;" | 18 || April 22 || Giants || 6–8 || Rueter || Daal || Nen (3) || Bank One Ballpark || 45,659 || 12–6 || San Francisco Giants at Arizona Diamondbacks Box Score, April 22, 2000 |- style="text-align:center; background:#fbb;" | 19 || April 23 || Giants || 7–12 || Nathan || Reynoso || None || Bank One Ballpark || 35,879 || 12–7 || San Francisco Giants at Arizona Diamondbacks Box Score, April 23, 2000 |- style="text-align:center; background:#bfb;" | 20 || April 25 || @ Phillies || 10–2 || Johnson || Brock || None || Veterans Stadium || 11,926 || 13–7 || Arizona Diamondbacks at Philadelphia Phillies Box Score, April 25, 2000 |- style="text-align:center; background:#bfb;" | 21 || April 26 || @ Phillies || 10–4 || Stottlemyre || Ashby || None || Veterans Stadium || 12,250 || 14–7 || Arizona Diamondbacks at Philadelphia Phillies Box Score, April 26, 2000 |- style="text-align:center; background:#fbb;" | 22 || April 27 || @ Phillies || 4–5 || Gomes || Kim || None || Veterans Stadium || 13,560 || 14–8 || Arizona Diamondbacks at Philadelphia Phillies Box Score, April 27, 2000 |- style="text-align:center; background:#fbb;" | 23 || April 28 || @ Cubs || 5–6 || Tapani || Springer || Aguilera (5) || Wrigley Field || 27,507 || 14–9 || Arizona Diamondbacks at Chicago Cubs Box Score, April 28, 2000 |- style="text-align:center; background:#bfb;" | 24 || April 29 || @ Cubs || 7–4 (10) || Mantei || Guthrie || Morgan (4) || Wrigley Field || 37,484 || 15–9 || Arizona Diamondbacks at Chicago Cubs Box Score, April 29, 2000 |- style="text-align:center; background:#bfb;" | 25 || April 30 || @ Cubs || 6–0 || Johnson || Lorraine || None || Wrigley Field || 37,274 || 16–9 || Arizona Diamondbacks at Chicago Cubs Box Score, April 30, 2000

|- style="text-align:center; background:#bfb;" | 26 || May 2 || @ Brewers || 5–1 || Stottlemyre || Haynes || None || Milwaukee County Stadium || 8,281 || 17–9 || Arizona Diamondbacks at Milwaukee Brewers Box Score, May 2, 2000 |- style="text-align:center; background:#fbb;" | 27 || May 3 || @ Brewers || 1–4 || Estrada || Daal || Wickman (4) || Milwaukee County Stadium || 9,600 || 17–10 || Arizona Diamondbacks at Milwaukee Brewers Box Score, May 3, 2000 |- style="text-align:center; background:#bfb;" | 28 || May 4 || @ Brewers || 6–2 || Reynoso || Stull || Kim (2) || Milwaukee County Stadium || 8,401 || 18–10 || Arizona Diamondbacks at Milwaukee Brewers Box Score, May 4, 2000 |- style="text-align:center; background:#bfb;" | 29 || May 5 || Padres || 5–3 || Johnson || Hitchcock || None || Bank One Ballpark || 42,297 || 19–10 || San Diego Padres at Arizona Diamondbacks Box Score, May 5, 2000 |- style="text-align:center; background:#bfb;" | 30 || May 6 || Padres || 10–5 || Anderson || Lopez || None || Bank One Ballpark || 36,827 || 20–10 || San Diego Padres at Arizona Diamondbacks Box Score, May 6, 2000 |- style="text-align:center; background:#bfb;" | 31 || May 7 || Padres || 8–1 || Stottlemyre || Clement || None || Bank One Ballpark || 38,060 || 21–10 || San Diego Padres at Arizona Diamondbacks Box Score, May 7, 2000 |- style="text-align:center; background:#bfb;" | 32 || May 8 || Dodgers || 15–7 || Daal || Park || None || Bank One Ballpark || 33,338 || 22–10 || Los Angeles Dodgers at Arizona Diamondbacks Box Score, May 8, 2000 |- style="text-align:center; background:#bfb;" | 33 || May 9 || Dodgers || 11–7 (12) || Padilla || Hershiser || None || Bank One Ballpark || 32,326 || 23–10 || Los Angeles Dodgers at Arizona Diamondbacks Box Score, May 9, 2000 |- style="text-align:center; background:#bfb;" | 34 || May 10 || Dodgers || 2–1 || Kim || Adams || None || Bank One Ballpark || 43,345 || 24–10 || Los Angeles Dodgers at Arizona Diamondbacks Box Score, May 10, 2000 |- style="text-align:center; background:#bfb;" | 35 || May 12 || @ Padres || 6–4 || Anderson || Clement || Kim (3) || Qualcomm Stadium || 24,391 || 25–10 || Arizona Diamondbacks at San Diego Padres Box Score, May 12, 2000 |- style="text-align:center; background:#bfb;" | 36 || May 13 || @ Padres || 6–2 || Stottlemyre || Spencer || Morgan (5) || Qualcomm Stadium || 44,044 || 26–10 || Arizona Diamondbacks at San Diego Padres Box Score, May 13, 2000 |- style="text-align:center; background:#fbb;" | 37 || May 14 || @ Padres || 1–3 || Meadows || Daal || Hoffman (6) || Qualcomm Stadium || 31,555 || 26–11 || San Diego Padres at Arizona Diamondbacks Box Score, May 7, 2000 |- style="text-align:center; background:#fbb;" | 38 || May 16 || @ Expos || 0–2 || Vazquez || Johnson || Hermanson (2) || Olympic Stadium || 11,898 || 26–12 || Arizona Diamondbacks at Montreal Expos Box Score, May 16, 2000 |- style="text-align:center; background:#fbb;" | 39 || May 17 || @ Expos || 2–10 || Pavano || Reynoso || None || Olympic Stadium || 8,766 || 26–13 || Arizona Diamondbacks at Montreal Expos Box Score, May 17, 2000 |- style="text-align:center; background:#bfb;" | 40 || May 18 || @ Expos || 8–6 || Kim || Telford || None || Olympic Stadium || 11,073 || 27–13 || San Diego Padres at Arizona Diamondbacks Box Score, May 7, 2000 |- style="text-align:center; background:#fbb;" | 41 || May 19 || @ Mets || 3–4 || Jones || Stottlemyre || Benitez (10) || Shea Stadium || 25,292 || 27–14 || Arizona Diamondbacks at New York Mets Box Score, May 19, 2000 |- style="text-align:center; background:#fbb;" | 42 || May 20 || @ Mets || 7–8 || Hampton || Daal || Benitez (11) || Shea Stadium || 37,121 || 27–15 || Arizona Diamondbacks at New York Mets Box Score, May 20, 2000 |- style="text-align:center; background:#fbb;" | 43 || May 21 || @ Mets || 6–7 || Wendell || Kim || None || Shea Stadium || 38,826 || 27–16 || Arizona Diamondbacks at New York Mets Box Score, May 21, 2000 |- style="text-align:center; background:#bfb;" | 44 || May 23 || Pirates || 6–1 || Anderson || Anderson || None || Bank One Ballpark || 31,726 || 28–16 || Pittsburgh Pirates at Arizona Diamondbacks Box Score, May 23, 2000 |- style="text-align:center; background:#bfb;" | 45 || May 24 || Pirates || 6–5 || Stottlemyre || Schmidt || Kim (4) || Bank One Ballpark || 30,462 || 29–16 || Pittsburgh Pirates at Arizona Diamondbacks Box Score, May 24, 2000 |- style="text-align:center; background:#bfb;"