Isaacs is a surname. Notable people with the surname include:
Alick Isaacs (1921–1967), Scottish virologist Avrom Isaacs, Canadian art dealer Bertha Isaacs, Bahamian tennis player and women's rights activist Betty Isaacs, (1894–1971), New Zealand sculptor and textile designer Charles Edward Isaacs (1811–1860), American anatomist and physiologist David Isaacs (writer), American screenwriter Don Isaacs (1919–1998), American sound editor Emma Isaacs, Australian entrepreneur Erwin Isaacs, South African football player George Isaacs, English politician and trade unionist Gregory Isaacs, Jamaican reggae musician Ike Isaacs (1923–1981), American jazz bassist Ike Isaacs (1919–1996), Burmese-British jazz guitarist Iorrie Isaacs, Wales rugby player Isaac Isaacs, Australian politician, jurist and Governor-General Jason Isaacs, English actor Jeremy Isaacs, Scottish television producer and executive John Isaacs, African-American basketball player John Dove Isaacs, American oceanic scientist Jorge Isaacs, Colombian writer, politician and soldier Kendal Isaacs, Bahamian politician and Leader of the Opposition Levi Isaacs (1860–1913), Australian tobacconist and Jewish lay leader Lewis Henry Isaacs, English architect, surveyor, and politician Mark Isaacs, Australian composer and pianist Martin Isaacs (1940–2025), American mathematician Nathaniel Isaacs, English adventurer Pamela Isaacs, American actress and singer Rufus Isaacs, 1st Marquess of Reading, English politician and jurist Rufus Isaacs (game theorist), American mathematician Sam Isaacs, Australian Aboriginal stockman Samuel Myer Isaacs, American educator Sonya Isaacs, American country singer Stan Isaacs, American sportswriter Susan Isaacs, American novelist and screenwriter Susan Sutherland Isaacs, English educational psychologist and psychoanalyst Susie Isaacs, American poker player
Fictional characters Jeff Isaacs, from Degrassi: The Next Generation Doctor Sam Isaacs, from Resident Evil (film series) Toby Isaacs, from Degrassi: The Next Generation Melanie Isaacs from Disgrace