Macromphaliinae is a subfamily of the moth family Lasiocampidae. The subfamily was first described by John G. Franclemont in 1973.
Genera Apotolype Franclemont, 1973 Artace Walker, 1855 Hypopacha Neumoegen & Dyar, 1893 Macromphalia C. & R. Felder, 1874 Mesera Walker, 1855 Titya Walker, 1855 Tolype Hübner, Tytocha Schaus, 1924