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Wolfsohn is a German language surname, which means "son of Wolf". Alternative spellings include Wolffsohn, Wolfssohn, and Wolffssohn. The name may refer to:
Aaron Halle-Wolfssohn (1754–1835), German translator and writer Alfred Wolfsohn (1896–1962), German singing teacher David Wolffsohn (1856–1914), German businessman and Zionist activist Michael Wolffsohn (born 1947), German historian
See also Wolfson Wolffsohn's viscacha Wolffsohn's leaf-eared mouse