Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.
ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide (AICA ribonucleotide).
It has two functions:
- 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
In this step, AICA ribonucleotide is formylated, with the formyl group being transferred from the cofactor 5,10-methylenetetrahydrofolate (5,10-CH2-THF).
- IMP cyclohydrolase
This enzyme forms the purine ring of inosine monophosphate by dehydration and cyclisation of N-formyl AICA ribonucleotide.
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