Big B may refer to:
Amitabh Bachchan or Big B (born 1942), Indian actor Big B Drugs, a defunct American drugstore chain Big B (film), a 2007 Malayalam film Big B (rapper) (born 1972), American rapper A character in the Infernal Affairs film series Buckethead, an American guitarist
See also Bigby (disambiguation) Biggby Coffee, pronounced big-B