Glutamyl aminopeptidase () is an enzyme that in humans is encoded by the ENPEP gene.
Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.
Alternative names The enzyme has had a number of other names, including aminopeptidase A, aspartate aminopeptidase, angiotensinase A, glutamyl peptidase, Ca2+-activated glutamate aminopeptidase, membrane aminopeptidase II, antigen BP-1/6C3 of mouse B lymphocytes, L-aspartate aminopeptidase, and angiotensinase A2. The human gene has also been designated CD249 (cluster of differentiation 249)
References
External links The MEROPS online database for peptidases and their inhibitors: M01.003