James Hepburn may refer to:
James Hepburn (bishop) (died 1524), Bishop of Moray James Hepburn, 4th Earl of Bothwell (c. 1534–1578), Scottish ruler, Duke of Orkney, the third husband of Mary, Queen of Scots Bonaventure Hepburn (James Hepburn, 1573–1621), Scottish orientalist James Hepburn Campbell (1820–1895), American politician and diplomat James Curtis Hepburn (1815–1911), American missionary James de Congalton Hepburn (1878–1955), Canadian MPP Jamie Hepburn (born 1979), Scottish politician James Hepburn (ornithologist) (1811–1869), English ornithologist Jock Hepburn (c. 1860–?), birth name James, Scottish footballer (Alloa Athletic and Scotland) James Hepburn (golfer) (1876–1945), golfer from Scotland James Hepburn, pseudonymous author of Farewell America: The Plot to Kill JFK