MHC may refer to:
Biology Major histocompatibility complex, a highly polymorphic region on chromosome 6 with genes particularly involved in immune functions Myosin heavy chain, part of the motor protein myosin's quaternary protein structure
Colleges Mars Hill College (now Mars Hill University), a college in Mars Hill, North Carolina, USA Mount Holyoke College, a college in South Hadley, Massachusetts, USA William E. Macaulay Honors College, an honors college within the City University of New York
Health Managed health care Mental health counselor Metropolitan Hospital Center, East Harlem, New York City
Sports Malaysian Hockey Confederation Mediterranean Handball Confederation Mid Hudson Conference Milwaukee Hurling Club
Other Maimonides Heritage Center Massachusetts Historical Commission Mile High City, common nickname for the city of Denver, Colorado, due to its elevation of exactly one mile above sea level Mile high club Mochoʼ language (ISO 639:mhc), a moribund Mayan language spoken in Chiapas, Mexico Mocopulli Airport (IATA: MHC), Dalcahue, Los Lagos, Chile Model of hierarchical complexity Mohawk–Hudson convergence, a meteorological phenomenon Murphy-Hoffman Company Museum of the History of Catalonia A US Navy hull classification symbol: Coastal minehunter (MHC)