Mosca may refer to:

Places Italian name of Moscow Mosca, Colorado, United States Mosca Pass, mountain pass in Alamosa County in the Rocky Mountains of Colorado in the United States Ponte Mosca, historic bridge in Turin, region of Piedmont, Italy

Other uses Mosca's, a restaurant near New Orleans in Avondale, Louisiana, United States Mosca-Bystritsky MBbis, fighter aircraft developed and used by the Imperial Russian Air Service during the First World War Polikarpov I-16, referred to by republicans during the Spanish Civil War as moscas (flies) Mosca (surname) Mosca of Montelepre, an antagonist in The Godfather III Christian "Mosca" Gomez, one of the main characters of children's telenovela Chiquititas