Highsmith is a surname. Notable people with the surname include:
Alex Highsmith (born 1997), American professional football player Alonzo Highsmith (born 1965), American professional football player Benjamin Franklin Highsmith (1817–1905), Texian and American soldier and Texas Ranger Carol M. Highsmith (born 1946) American photographer, author, and publisher Don Highsmith (born 1948), American professional football player Haywood Highsmith (born 1996), American professional basketball player Jim Highsmith (born 1945), author of multiple books in the field of software development methodology Malcijah Benjamin Highsmith (1804–1849), Texian, American and Confederate soldier Margaret Highsmith Dickson, Democratic member of the North Carolina General Assembly Patricia Highsmith (1921–1995), American novelist Samuel Highsmith (1804–1849), Texian and American soldier and Texas Ranger
See also Highsmith (album), a 2017 album by Craig Taborn and Ikue Mori