An extended period of tornado activity occurred between April 20–27, 2007. The outbreak sequence is best known for producing a deadly tornado that struck the border cities of Piedras Negras, Coahuila (rated F4), and Eagle Pass, Texas (rated EF3), along the United States-Mexican border on April 24, 2007, killing ten people. Other strong tornadoes also caused damage and injuries in or near the towns of Moorefield, Nebraska, Gothenburg, Nebraska, Cactus, Texas, and Tulia, Texas. In all, 91 tornadoes were confirmed causing 10 fatalities and injuring at least 270 others.

Meteorological synopsis Activity was not widespread on April 20, but two strong tornadoes were confirmed in southwestern Nebraska from a single supercell that suddenly developed. The first was an EF3 tornado near Moorefield, Nebraska, which destroyed six farmsteads and injured two people. A large wedge EF2 tornado touched down near Gothenburg and injured nine people as it crossed over Interstate 80, before moving north through rural areas, damaging several farms.

On April 20, the SPC issued a moderate risk of severe thunderstorms for the Texas and Oklahoma Panhandles and the southwestern part of Kansas for April 21, which was extended into Nebraska later. Widespread severe weather developed that evening, although the primary result of the supercells was large hail. The meteorological synopsis was virtually identical to March 28 except for the fact that the air mass was not as unstable. In total, 24 tornadoes were confirmed Despite this, five EF2 tornadoes were confirmed in the Texas Panhandle that day. A large high-end EF2 tornado struck Cactus, Texas damaging or destroying numerous structures and injuring 14 people. Another high-end EF2 tornado struck community was Tulia, Texas where more structures were heavily damaged or destroyed and three people were injured. Over 100 reports of hail were recorded on this day as well. Only isolated severe weather activity occurred on April 22 with only one tornado being confirmed.

A severe weather outbreak was forecast for April 23 and 24 across the southern Plains. In the early morning hours of April 22, the SPC issued a moderate risk of severe weather for South Central Kansas, Central Oklahoma, and North Central Texas. This was an extremely rare issuance; at the time, this was only the third time that such a risk been issued so far in advance with the others being for June 10, 2005 and January 2, 2006, although neither time did it result in a major outbreak. Several tornadic storms were reported across northwest and south-central Texas, far western Oklahoma, and southwest Kansas on April 23. A total of 29 tornadoes were confirmed, although most stayed over sparsely populated area. The activity quickly redeveloped late on the morning of April 24. Later in the afternoon, the risk that day was upgraded to a high risk over parts of East Texas. Tornadoes, along with large hail and damaging winds, occurred in the afternoon and evening hours across the Plains. Although there was virtually no activity in the high risk area, several tornadoes occurred elsewhere. One large tornadic supercell produced a deadly F4 tornado in Piedras Negras, Coahuila in Mexico killing three people, the same supercell moved across the United States-Mexican border and into the Eagle Pass, Texas metro, with reports of significant damage on the U.S. side of the border and at least seven deaths and 80 injuries from the EF3 tornado, plus at least three deaths and at least 153 injuries across the river in Piedras Negras. Isolated tornadic activity occurred on April 25, but a non-tornadic fatality occurred in Lake Village, Arkansas when winds capsized a boat on Lake Chicot.

Several tornadoes developed across the Midwest and into the Tennessee Valley on the afternoon and evening of April 26. The hardest hit communities were LaPorte, Indiana, which was struck by two EF1 tornadoes, and New Tazewell, Tennessee, which was also hit by an EF1 tornado, where structural damage was reported in both communities, and dozens of houses were damaged or destroyed. Several other scattered tornadoes were reported, along with widespread wind damage. In total, seven people were injured. Four other tornadoes were confirmed in Ohio and Illinois. In the final review of 2007, three EF0 tornadoes were confirmed on April 27. Two of which were in Missouri and the other touched down in Virginia.

Confirmed tornadoes

Note: Mexico used the Fujita Scale at the time the tornado that occurred was rated, hence the F4 rating.

April 20 event + List of confirmed tornadoes – Friday, April 20, 2007EF#LocationCounty / ParishStateStart Coord.Time (UTC)Path lengthMax widthSummary EF3ESE of Moorefield to SW of BradyFrontier, LincolnNE02:16–02:46An intense tornado began its damage by tearing the roof and attached garage off of a house, blowing the windows out of another, and destroying a third. Also in this area, the tornado destroyed grain bins and outbuildings, carried a horse trailer 50 yards, overturned irrigation pivots, scattered irrigation pipe, destroyed a wind mill, and pulled a fence line out of the ground. As the tornado entered Lincoln County, it destroyed a large storage building, removed the roof and an exterior wall from one home, and completely destroyed an unanchored home. Numerous trees and power poles were snapped along the path. Two people were injured when they were thrown from the unanchored home. EF2SSW of Gothenburg to SW of CallawayDawson, CusterNE03:02–03:40This large wedge tornado injured nine people as it crossed Interstate 80, where several vehicles and semis were blown off the road. Nearly a dozen head of cattle were killed nearby, and a farmhouse lost half of its roof and had many windows blown out. The tornado then destroyed a barn, chicken house, milk house, an oil bin, and two dryer bins. Irrigation pivots were overturned, and numerous trees and power poles were snapped along the path.

April 21 event + List of confirmed tornadoes – Saturday, April 21, 2007EF#LocationCounty / ParishStateStart Coord.Time (UTC)Path lengthMax widthSummary EF0W of LittlefieldLambTX23:20–23:24Weak tornado over open fields with no damage. EF0SE of CampoBacaCO23:25–23:32Tornado remained over open fields, causing no damage. EF0SW of GranadaProwersCO23:25–23:35Large, slow-moving tornado remained over open country with no damage. EF1NW of Boys Ranch to SE of HartleyOldham, HartleyTX23:51–00:27Power poles, signs, and fences were damaged. EF0N of BethuneKit CarsonCO23:54–23:55 A shed was lofted and flipped over, resulting in damage to a hay bailer and two grain bins. EF2N of Fieldton to NW of KressLamb, Hale, Castro, Swisher TX23:57–00:36In Lamb County, this long-tracked tornado damaged irrigation pivots and power poles, tore the roofs off of two brick buildings, heavily damaged five homes, destroyed lightweight metal structures, damaged farm equipment, and blew skirting from a mobile home as it passed near Olton. Irrigation pivots were destroyed and power poles were snapped in Hale, Castro, and Swisher Counties before the tornado dissipated. A dog and some livestock was killed, and one person was injured. EF2SW of Dumas to SE of StratfordMoore, ShermanTX00:16–00:52Large wedge tornado caused major damage in the town of Cactus. Ten mobile homes were destroyed with others heavily damaged. Many homes and businesses sustained varying degrees of damage. 14 people were injured. EF0SE of PlankintonAuroraSD00:48–00:58Tornado remained over open country with no damage. EF2E of Four Way to SE of DumasMooreTX00:50–01:15Power poles were snapped, a fence was downed, and large hay bales were tossed around. EF2TuliaSwisherTX00:57–01:0130 homes and 20 businesses in Tulia were damaged or destroyed, with a supermarket and industrial buildings sustaining major damage. A storm chaser's vehicle was thrown into a brick building, and a semi-truck was blown into the chase vehicle. A collection of antique cars in a storage building were also damaged by the collapse of overhead doors and roof purlins, and 5 mobile homes were destroyed. A car dealership was heavily damaged, with 41 vehicles damaged by flying debris, and a motor home on the property was overturned. Damage and economic loss was estimated at $2 million. 3 people were injured. EF0E of DumasMooreTX01:06–01:08Tornado remained over open country with no damage. EF1NE of TuliaSwisherTX01:11–01:16A large barn was heavily damaged. EF0W of SunrayMooreTX01:19–01:23Tornado remained over open country with no damage. EF0E of HappySwisherTX01:20–01:24Large tornado remained over open country with no damage. EF1NE of Sunray to SE of StratfordMoore, ShermanTX01:36–01:50A barn was destroyed, hog barns sustained roof damage, and empty rail cars were overturned. EF1E of WaysideArmstrongTX01:45–01:55Damage was limited to power poles. EF1E of Dumas to SW of SunrayMooreTX01:45–02:00A feedyard sustained minor damage and double wooden power poles were snapped. EF0SE of EsmondKingsburySD01:56–01:58Brief tornado caused no damage. EF0SE of LautzShermanTX01:58–02:12Large tornado remained over open country with no damage. EF1SW of SunrayMooreTX01:59–02:02Property damage occurred and double wooden power poles were snapped. EF1SE of CanyonRandallTX02:00–02:15Tornado damaged power poles and farm structures. A horse was killed. EF2NE of Claude to SE of PanhandleArmstrong, CarsonTX02:35–03:10Power poles were damaged while tractors, turbines, vehicles and cotton presser box cars were moved and/or tossed, some for considerable distances. EF0E of ClaudeArmstrongTX02:40–03:45Tornado remained over open country with no damage. EF1W of Alanreed to SW of Kings MillGrayTX02:50–03:10A house lost part of its roof, power poles were snapped, and storage buildings and outbuildings were destroyed.

April 22 event + List of confirmed tornadoes – Sunday, April 22, 2007EF#LocationCounty / ParishStateStart Coord.Time (UTC)Path lengthMax widthSummary EF0SW of OsmondPierceNE19:43–19:44No damage occurred as a tornado remained over open country.

April 23 event