Schlessinger is a German surname meaning "from Silesia" (German: Schlesien). The Czechized form of the surname is Šlesingr (; feminine: Šlesingrová). Notable people with the surname include:
Arthur M. Schlesinger Sr. (1888–1965), American historian and professor David Schlessinger (born 1936), Canadian-American biochemist, microbiologist and geneticist Joseph Schlessinger (born 1945), Israeli-American biochemist Laura Schlessinger (born 1947), American radio host and author Michael Schlessinger, American mathematician Michal Šlesingr (born 1983), Czech biathlete
See also Schlessinger Media, educational video distributor Schlesinger Shlesinger Slesinger