Cacamatzin was a 15th-century Aztec noble — the eldest son of the cihuacoatl, TlacaelelChimalpahin (1997): pp. 52–53, 140–141. — and warrior who held the title of Tlacochcalcatl. His mother was princess Maquiztzin.Chimalpahin (1997): pp. 48–49.

He had twelve children, only three of whom are known:Chimalpahin (1997): pp. 140–141 A female (name unknown), who married Nezahualpilli, the tlatoani of Texcoco. The pair had a son, named Cacamatzin after his grandfather, who succeeded his father as ruler of Texcoco. Tlacaelel II, named after his grandfather, who also became cihuacoatl.Chimalpahin (1997): pp. 54–55, 140–141. Chicuey or Chicome Axochitzin, a warrior whose daughter became the mistress of Juan Rodríguez de Villafuerte, a Spanish conquistador.

Cacamatzin was killed by the Purépecha after being captured in battle.

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