Francis Balfour may refer to:
Francis Balfour (medical officer) ( 1744–1818), Anglo-Indian medical officer and medical author Francis Maitland Balfour (1851–1882), British biologist Francis Balfour (bishop) (1860–1924), assistant bishop of Bloemfontein Francis Balfour (colonial administrator) (1884–1965), British military officer and colonial administrator