Propylamphetamine (code name PAL-424; also known as N-propylamphetamine or NPA) is a central nervous system psychostimulant and substituted amphetamine which was never marketed. It was first developed in the 1970s, mainly for research into the metabolism of, and as a comparison tool to, other amphetamines.
Propylamphetamine is inactive as a dopamine releasing agent in vitro and instead acts as a low-potency dopamine reuptake inhibitor with an of 1,013nM. The drug can be N-dealkylated to form amphetamine (10–20% excreted in urine after 24hours). A study in rats found propylamphetamine to be approximately 4-fold less potent than amphetamine.
+ Compound Ref Phenethylamine 10.9 39.5 >10,000 d-Amphetamine 6.6–10.2 5.8–24.8 698–1,765 d-Methamphetamine 12.3–14.3 8.5–40.4 736–1,292 Ethylamphetamine 88.5 d-Ethylamphetamine 28.8 44.1 333.0 Propylamphetamine (1,013) Butylamphetamine (>10,000) Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs:
See also Methamphetamine Ethylamphetamine Isopropylamphetamine Butylamphetamine Fenproporex Mefenorex Phenylpropylaminopentane (PPAP)
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