TSR may refer to:
Science and technology Terminate-and-stay-resident program, a type of MS-DOS computer program Thermochemical sulfate reduction, reducing sulfate to sulfide Tip-speed ratio, of a wind turbines Traffic-sign recognition, by equipment in vehicles
Military BAC TSR-2, a prototype British bomber TSR I and II, prototypes of the Fairey Swordfish torpedo bomber FN Tactical Sport Rifle Transvaal Scottish Regiment
Arts and media TSR, Inc. (Tactical Studies Rules), 1973–1997 game publishing company Télévision Suisse Romande, a French-language Swiss TV channel Full Metal Panic! The Second Raid, an anime Team Sonic Racing, a video game True Symphonic Rockestra, an opera-oriented project "T.S.R. (Toilet Stool Rap)", song from Biz Markie's album I Need a Haircut The Shade Room, media company TSR Records
Transportation
Train Temporary speed restriction, UK railway term Telford Steam Railway, UK Texas State Railroad, US Toronto Street Railway (horse-drawn), 1861-1891 Former Toronto Suburban Railway Trans-Siberian Railway Treno Servizio Regionale, Italian trains
Other modes of transportation Timișoara Traian Vuia International Airport, Romania, IATA code Traffic-sign recognition, by equipment in vehicles Travelling stock route, an authorised thoroughfare for walking livestock across Australia
Other uses Total shareholder return Traditional Spelling Revised, a relatively conservative English-language spelling reform Tokyo Sun Rockers, a Japanese basketball team