M50 or M-50 may refer to:

Military equipment M50 joint service general purpose mask, United States military gas mask M50 Super Sherman, an Israeli tank M50 Reising submachine gun, an American submachine gun M50 Ontos, an American tank destroyer Madsen M-50, a Danish submachine gun Myasishchev M-50, 'Bounder', a Soviet bomber Obusier de 155 mm Modèle 50 or M 50, a French howitzer introduced in 1952

Transportation M50 (New York City bus), a New York City Bus route in Manhattan BMW M50, a 1989 automobile piston engine Suzuki Boulevard M50, an 800cc V-twin muscle cruiser by Suzuki Motor Company The FAA identifier of Boardman Airport, Oregon, United States

Roads M-50 (Michigan highway), United States M50 motorway (Great Britain), in the West Midlands / South West M50 motorway (Ireland), a Dublin ring road M-50 (Spain), a Madrid ring road M50 (Cape Town), a Metropolitan Route in Cape Town, South Africa M50 (Pietermaritzburg), a Metropolitan Route in Pietermaritzburg, South Africa

Other uses 50 Moganshan Road (M50), Shanghai's contemporary art district Messier 50 (M50), an open star cluster in the constellation Monoceros M 50, an age group for Masters athletics (athletes aged 35+) Canon EOS M50 Camera BMW M50 Engine

See also Model 50 (disambiguation)