Gutfreund () is a surname of German origin. Notable people with the surname include:
Amir Gutfreund (1963-2015), Israeli writer Hanoch Gutfreund, Israeli Andre Aisenstadt Chair in theoretical physics, and former President, of the Hebrew University of Jerusalem Herbert Gutfreund (1921–2021), British biochemist John Gutfreund (1929–2016), American businessman Otto Gutfreund (1889–1927), Czech sculptor Yossef Gutfreund (1932–1972), Israeli wrestling coach and referee who was killed in the Munich massacre at the 1972 Olympic Games Andre R. Guttfreund (born 1946), Salvadoran film director and producer
See also Goodfriend