Gran Sasso is Gran Sasso d'Italia, the highest mountain in central Italy.

Gran Sasso may also refer to:

Isola del Gran Sasso d'Italia, a town in Italy near the mountain Gran Sasso e Monti della Laga National Park, which surrounds the town and mountain

Laboratori Nazionali del Gran Sasso, the largest underground laboratory in the world, under the midpoint of the tunnel

See also Capannelle Pass, passes near the Gran Sasso in the Apennines, Italy