What's Up, Doc? may refer to:
Uses related to Bugs Bunny "What's up, doc?", a catchphrase used by Bugs Bunny What's Up, Doc? (1950 film), an animated cartoon short What's Up Doc? (Australian TV series), a 1990s children's program featuring Looney Tunes cartoons What's Up Doc? (British TV series), a 1990s Saturday-morning children's program featuring Looney Tunes cartoons
Other film and television What's Up, Doc? (1972 film), a screwball comedy film starring Barbra Streisand and Ryan O'Neal "What's Up, Doc?" (Cheers), an episode "What's Up Doc?", an episode of Family Matters "What's Up, Doc?", an episode of M*A*S*H
Other uses "What's Up Doc? (Can We Rock)", a song by Fu-Schnickens, featuring Shaquille O'Neal What's Up Doc?, a 2010 book by Hilary Jones
See also What's up (disambiguation)