The following is an outline of the participation of Panamanian football teams in the regional tournaments offered by CONCACAF. Since 1988, Panama has almost always sent at least one team to the competitions. The first appearance by a Panamanian team was in the 1988 CONCACAF Champions' Cup, when Plaza Amador played in the first round.

The best run for a Panamanian team was in 2002, when Árabe Unido finished runner-up in the UNCAF Interclub Cup.

Teams from Panama have participated in nearly every edition of the CONCACAF Champions Cup (2008–present). Their best results at the tournament have been runs to the quarter-finals on five occasions: Árabe Unido in 2010, 2014, and 2017, Tauro in 2018, and Indepediente in 2019.

Panamanian teams also competed in every edition of the CONCACAF League, which began in 2017 and ended in 2021. Sides from Panama reached the semi-finals of the tournament four times: Árabe Unido in 2017 and 2018, Plaza Amador in 2017, and Tauro in 2018.

Panamanian teams now compete in the CONCACAF Central American Cup, which began in 2023.

CONCACAF Champions Cup era (1962–2008, 2024–present) SeasonTeamRoundOpponent1st leg2nd legAggregate1988Plaza AmadorFirst round Alajuelense0–21–21–41989Plaza AmadorFirst round Coke Milpross1–14–15–1Second round Pumas UNAM0–40–60–10Deportivo La PrevisoraPreliminary round America Managua1–12–03–1First round Duurly's3–06–29–2Second round UDG0–15–55–61990TauroFirst round Firpo1–10–31–4Deportivo La PrevisoraFirst round Alianza1–100–21–121991Plaza AmadorFirst round Alajuelense1–40–71–11TauroFirst round América Managua5–00–05–0Second round Saprissa1–30–21–51992EurokickersFirst round SF Bay Blackhawks0–100–10–11TauroFirst round Real Estelí2–05–17–1Second round Dallas Rockets1–32–23–51993Sporting ColonPreliminary round Comunicaciones0–11–31–4Plaza AmadorPreliminary round Juventus Managua5–04–09–0First round Firpo2–20–62–81995Árabe UnidoFirst round FAS0–41–11–5PROJUSAFirst round Juventus Managua1–12–13–1Second round Guadalajara0–50–100–151996CosmosFirst round Comunicaciones0–20–40–6Árabe UnidoFirst round Real Estelí1–11–02–1Second round Victoria0–11–21–31997Euro KickersPreliminary round Dariangén4–21–45–6TauroFirst round Cartaginés0–52–42–9Return to Champions Cup format (2024–present)2024IndependienteFirst round New England Revolution0–10–30–42026Sporting San MiguelitoFirst round LA Galaxy1–10–01–1 (a)

CONCACAF Champions League era (2008–2023)

SeasonTeamRoundOpponentHomeAwayAggregate2008–09San FranciscoPreliminary round Jalapa5–00–15–1Group stage Pumas UNAM1–10–64th Houston Dynamo0–01–2 Firpo2–30–1TauroPreliminary round Chivas USA2–01–13–1Group stage Puerto Rico Islanders2–21–23rd Municipal2–12–2 Santos Laguna2–00–32009–10San FranciscoPreliminary round San Juan Jabloteh2–00–32–3Árabe UnidoPreliminary round Olimpia1–01–22–2 (a)Group stage Pachuca4–10–22nd Houston Dynamo1–11–5 Isidro Metapán6–01–0Quarter-finals Cruz Azul0–10–30–42010–11TauroPreliminary round Marathón0–32–12–4San FranciscoPreliminary round Cruz Azul2–30–62–9Árabe UnidoGroup stage Real Salt Lake2–31–24th Toronto FC1–00–1 Cruz Azul0–60–22011–12San FranciscoPreliminary round Seattle Sounders FC1–00–21–2TauroGroup stage Toronto FC1–20–14th Pumas UNAM0–00–1 FC Dallas5–31–12012–13TauroGroup stage Real Salt Lake0–10–23rd Herediano0–11–2ChorrilloGroup stage Monterrey0–60–53rd Municipal1–21–2SeasonTeamRoundOpponentHomeAwayAggregate2013–14Sporting San MiguelitoGroup stage América0–10–33rd Alajuelense1–00–2Árabe UnidoGroup stage W Connection3–12–01st Houston Dynamo1–01–2Quarter-finals Alajuelense0–20–00–22014–15TauroGroup stage Waterhouse1–21–43rd D.C. United0–10–2ChorrilloGroup stage Cruz Azul1–00–33rd Alajuelense1–10–12015–16San FranciscoGroup stage Querétaro2–10–22nd Verdes8–01–2Árabe UnidoGroup stage Montego Bay United3–02–12nd D.C. United0–10–22016–17Plaza AmadorGroup stage Herediano1–10–23rd Tigres UANL1–01–3Árabe UnidoGroup stage Monterrey2–13–21st Don Bosco2–05–2Quarter-finals FC Dallas2–10–42–52018TauroRound of 16 FC Dallas1–02–33–3 (a)Quarter-finals América1–30–41–72019IndependienteRound of 16 Toronto FC4–01–15–1Quarter-finals Sporting Kansas City2–10–32–4

CONCACAF League (2017–2021)

SeasonTeamRoundOpponentHomeAwayAggregate2017ChorrilloRound of 16 Honduras Progresso1–01–02–0Quarter-finals Santos de Guápiles0–11–00–2Plaza AmadorRound of 16 Portmore United1–00–11–1 Quarter-finals Walter Ferreti2–10–02–1Semi-finals Olimpia1–71–12–8Árabe UnidoRound of 16 Central3–02–15–1Quarter-finals Águila0–12–02–1Semi-finals Santos de Guápiles0–00–10–12018UniversitarioRound of 16 Diriangén3–14–07–1Quarter-finals Herediano1–20–31–4TauroRound of 16 Real España1–01–12–1Quarter-finals Walter Ferreti3–14–07–1Semi-finals Motagua2–10–22–3Árabe UnidoRound of 16 Arnett Gardens3–01–24–2Quarter-finals FAS3–11–04–1Semi-finals Herediano1–00–21–22019TauroRound of 16 Alianza1–00–21–2IndependienteRound of 16 Robinhood2–11–13–2Quarter-finals Saprissa0–00–00–0San FranciscoPreliminary round Alianza0–11–51–62020TauroRound of 16 Forge FC1–2N/AIndependientePreliminary round Antigua GFC0–0 N/ASan FranciscoRound of 16 Alajuelense0–1N/A2021IndependienteRound of 16 Forge FC0–20–00–2Plaza AmadorRound of 16 Santos de Guápiles0–20–10–3UniversitarioPreliminary round SamaritaineN/A3–0 (w/o)Round of 16 Motagua2–20–12–3

References