Manion may refer to:
Clarence Manion (1896-1979), American conservative and Dean of Notre Dame. Daniel Anthony Manion (1942-2024), United States federal judge for the United States Court of Appeals for the Seventh Circuit Ed Manion (born 1952), American saxophone player Jack Manion (1877–1959), San Francisco Police Sergeant John Manion (1931-2010), Canadian civil servant Katherine Manion (1867–1956), American physician Robert James Manion (1881–1943), leader of the Conservative Party of Canada Manyam Zamindar of French Yanam.
See also Mannion James Mannon (born 1942), American sociologist