O'Reilly is a surname of Irish origin (the article includes a list of people and fictional characters with the surname).

O'Reilly may also refer to:

Businesses and organisations O'Reilly Auto Parts, American automobile parts retailer O'Reilly Foundation, a personal charitable trust O'Reilly Media, American learning company

Other uses O'Reilly (horse) (1993–2014), a New Zealand racehorse O'Reilly, Queensland, a place in Australia O'Reilly Open Source Convention, for the discussion of open source software

See also Reily (disambiguation) Reilly (disambiguation) Riley (disambiguation) Lucas Oil Indianapolis Raceway Park, formerly O'Reilly Raceway Park The O'Reilly Factor, American political talk show