The tallest building in Buffalo, the second largest city in New York State, is currently the Seneca One Tower, which stands 529 feet (161 m) tall. As of 2026, Buffalo has 17 structures taller than 250 ft (76 m).

Buffalo has a rich tradition for architecture. Among the first true skyscrapers built in the city were the Prudential (Guaranty) Building and the Ellicott Square Building, both being built in the 1890s. A number of the tallest municipal buildings in the country were also built in the city, such as Buffalo City Hall, which continues to dominate the skyline. The city is also home to a large collection of large grain elevators, many of which rise above 150 ft (46 m). Construction of high rise buildings has increased in recent years after decades of relative dormancy, in addition to the retro-fitting of many old structures.

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Tallest buildings This lists ranks Buffalo buildings that stand at least 128 feet (39 m) tall, based on standard height measurement. This includes spires and architectural details but does not include antenna masts. Existing structures are included for ranking purposes based on present height.

RankName ImageHeightfeet / mFloorsYear Notes 1 Seneca One Tower 529 / 161 40 1972 Tallest building in the city. Tallest building constructed in the 1970s. Previously known as One Seneca Tower (2013–2017), One HSBC Center (1999–2013), Marine Midland Center (1972–1999). 2 Rand Building 405 / 123 29 1929 Tallest building constructed in the 1920s. 3 Buffalo City Hall 398 / 121 32 1931 Tallest building constructed in the 1930s.City Hall History 4 Main Place Tower 350 / 107 26 1969 Tallest building constructed in the 1960s. 5 Liberty Building 345 / 105 23 1925 6 One M&T Plaza 317 / 97 21 1966 7 Electric Tower 294 / 90 14 1912 Also known as the Niagara Mohawk Building. Tallest building constructed in the 1910s. 8 Saint Paul's Episcopal Cathedral 275 / 84 1851 Tallest building constructed in the 1850s 9 50 Fountain Plaza 275 / 84 17 1990 Tallest building constructed in the 1990s. Formerly known as Key Center North Tower. 10 Buffalo Central Terminal 271 / 83 20 1929 Also known as the New York Central Terminal Complex. 11 Erie County Hall 270 / 82 1876 Tallest building constructed in the 1870s. Also known as County and City Hall. 12 Statler Hotel 265 / 81 19 1923 Also known as the Statler Towers. 13 10 Lafayette Square 263 / 80 23 1959 Tallest building constructed in the 1950s. Also known as the Tishman Building. 14 Verizon/AT&T Building 258 / 79 16 1913 Previously known as The Telephone Company Building. 15 Robert H. Jackson United States Courthouse 255 / 78 10 2011 Tallest building constructed in the 2010s.16Golisano Children's Hospital of Buffalo252 / 77 (est)122017 Formerly known as John R. Oishei Children's Hospital 17The Marin 250 / 76 17 1913 Formerly known as the Marine Trust Company Building; Main Seneca Building. 18Genesee Building/Hyatt Regency Hotel 249 / 76 16 1923Genesee Building/Hyatt Buffalo Architecture and History 19 Saint Louis Roman Catholic Church 246 / 75 1889 Tallest building constructed in the 1880s 20Old Post Office 244 / 74 1901 Now Erie Community College City Campus. Also known as U.S. Post Office 21 LECOM Harborcenter 240 / 73 (est) 20 2015 Connected to KeyBank Center 22 Saint Mary of Sorrows Roman Catholic Church 241 / 72 1891 Now King Urban Life Center 23The Avant 225 / 69 15 1973 / 2009Former Thaddeus J. Dulski Federal BuildingDulski Federal Building 24 40 Fountain Plaza 225 / 69 13 1990 Formerly known as Key Center South Tower 25Edward A. Rath County Office Building 223 / 68 16 1969 26Church of St. Stanislaus, Bishop and Martyr 217 / 66 1886 27Buffalo General Hospital Building A 213 / 65 16 1986 Tallest building constructed in the 1980s. 28 Wheeler Elevator 207 / 63 13 Also known as Buffalo RiverWorks; Agway/GLF East Work House 29 Concrete-Central Elevator 207 / 63 7 1915 30 Erie County Medical Center 195 / 59 13 1978 31Delaware North Building 194 / 59* 12 2015 *Height: 174/53 to roof level, 194/59 to top of mechanicals (Source: Developer) 32 Standard Elevator 194 / 59 1928 Also known as Pillsbury Elevator. 33Kaleida Health Gates Vascular Institute 190 / 58 10 2011 34 Marine A Elevator 190 / 58 11 1925 35 Superior Elevator 189 / 58 1925 Also known as Cargill "S" or Cargill Superior Elevator. 36 Main Court Building 188 / 57 13 1963 37Asbury Delaware Avenue United Methodist Church 184 / 56 1876 Also known as Delaware Avenue Methodist Episcopal Church. 38 Westminster Presbyterian Church 184 / 56 1859 39 Scott Bieler Clinical Sciences Center 182 / 56 11 2015 Part of Roswell Park Comprehensive Cancer Center.40Church of the Transfiguration180 / 551896 41 City Centre Condominiums 180 / 55 14 1993 42 Buffalo VA Medical Center 177 / 54 14 1950 43 Kreiner Malting Grain Elevator 177 / 54 1925 Also known as the Buffalo Malting Elevator. 44Corpus Christi Roman Catholic Church 175 / 53 1907 45 Connecting Terminal 174 / 53 1915 46Cargill Pool Elevator 174 / 53 1925 Also known as the Saskatchewan Cooperative Elevator. 47 The Pasquale 173 / 53 (est.) 13 2009 Tallest building constructed in the 2000s. Luxury condos. 48 10 Hertel Avenue 173 / 53 (est.) 13 1972 Part of the Marina Vista Apartments complex. Formerly known as Watergate II Apartments 1. Public housing. 49 12 Hertel Avenue 173 / 53 (est.) 13 1972 Part of the Marina Vista Apartments complex. Formerly known as Watergate II Apartments 2. Public housing. 50 Assumption Roman Catholic Church 170 / 52 1915 51 Prudential/Guaranty Building 167 / 51 13 1896 52AM&A Building 166 / 51 12 1948 Tallest building constructed in the 1940s. 53Ellicott Square Building 164 / 50 10 1896 54 First Presbyterian Church 164 / 50 1891 55Olympic Towers 161 / 49 11 1903 Also known as the Young Men's Christian Association Central Building. 56Richardson Olmsted Complex 161 / 49 4 1871 57 General Mills Plant 161 / 49 12 Also known as the Frontier Elevator. 58 800 West Ferry Street 161 / 49 (est.) 12 1929 High-rise condominium tower. 59 The Admiral 160 / 49 (est.) 12 1952 Part of the Marine Drive Apartments complex. Public housing. 60 The Bayshore 160 / 49 (est.) 12 1952 Part of the Marine Drive Apartments complex. Public housing. 61 The Coastline 160 / 49 (est.) 12 1952 Part of the Marine Drive Apartments complex. Public housing. 62 The Driftwood 160 / 49 (est.) 12 1952 Part of the Marine Drive Apartments complex. Public housing. 63 The Ebbtide 160 / 49 (est.) 12 1952 Part of the Marine Drive Apartments complex. Public housing. 64 Elmwood Square Apartments 160 / 49 (est.) 12 1973 Section 8 public housing for senior citizens. 65 The Flagstaff 160 / 49 (est.) 12 1952 Part of the Marine Drive Apartments complex. Public housing. 66 The Gulfstream 160 / 49 (est.) 12 1952 Part of the Marine Drive Apartments complex. Public housing. 67 M&T Center (Buffalo Savings Bank extension) 160 / 49 (est.) 12 1985 The building is a north side addition to the Buffalo Savings Bank 68 Marguerite Hall 160 / 49 (est.) 12 1966 D'Youville College dormitory 69 Riverview Manor 160 / 49 (est) 12 1977 Also known as Riverview Apartments. Apartment building for senior citizens. 70Buffalo City Court Building 154 / 47 (est.) 10 1974 71 St. Mary's Cement Storage Tanks 154 / 47 1910 Also known as the Spencer Kellogg Elevator 72American Grain Complex 151 / 46 10 1933 Also known as the Perot Malting Elevator; Genesee Brewing Elevator. 73 500 Pearl Street 151 / 46 12 2019 74 Lake & Rail Grain Elevator 151 / 46 9 1927 75Saint Adalbert's Basilica 151 / 46 1886 76 Swan Tower 148 / 45 10 1902 Also known as the Fidelity Trust Building. 77 Admiral's Walk Condominiums 147 / 45 (est.) 11 1990 Luxury condos. 78 Churchill Academic Tower 147 / 45 (est.) 11 1971 Houses Canisius University classrooms and lecture halls. 79 PSG Residences 147 / 45 (est.) 11 1978 Also known as Piotr Stadnitski Gardens. Apartment building for senior citizens. 80 Santa Maria Towers 147 / 45 (est.) 11 1984 Apartment building for senior citizens. 81Women and Children's Hospital of Buffalo 145 / 44 (est.) 11 1956 82 The Delaware Tower 142 / 43 (est.) 17 1962 83 Buffalo Athletic Club 141 / 43 (est.) 12 1922 84 Cathedral Place 140 / 43 (est.) 10 1906 Also known as the White Building. 85St. Francis de Sales Roman Catholic Church 140 / 43 (est.) 1928 86 42 Delaware Avenue 136 / 41 (est.) 11 1929 87 12 Fountain Plaza 133 / 41 (est.) 10 1983 Also known as the Norstar Building. 88 Lyndon B. Johnson Apartments 133 / 41 (est.) 10 1973 Apartment building for senior citizens. 89 Mary Agnes Manor 133 / 41 (est.) 10 1965 Apartment building for senior citizens. 90Roswell Park Cancer Institute 133 / 41 (est.) 10 1998 91 Baptist Manor Apartments 133 / 41 (est.) 16 197692 Clement Hall 133 / 41 11 1964 Residence hall at the University at Buffalo's South Campus. 93 Goodyear Hall 133 / 41 11 1960 Residence hall at the University at Buffalo's South Campus. 94 Kimball Tower 133 / 41 11 1957 Houses the University at Buffalo's School of Public Health and Health Professions. 95 Dun Building 130 / 40 10 1895 96 Erie County Court Building 130 / 40 (est) 8 1965 97Larkin @ Exchange 130 / 40 (est) 8 1912 Also known as the Larkin Building, Graphic Controls Corporation Building, Larkin Terminal Warehouse. 98 One Canalside 129 / 39 8 1962 / 2013 Formerly General William J. Donovan State Office Building. 99Buffalo General Hospital Building D 128 / 39 8 1901 Also known as Buffalo General Hospital Administration Building; Buffalo General Hospital East Wing. 100 Convention Tower 128 / 39 (est.) 12 1924 Also known as the Walbridge Building.

Tallest proposed or under construction This lists buildings (greater than 12 floors) that have been proposed in Buffalo.

NameHeightfeet / mFloorsYear ProposedStatus Notes Marine Drive Apartments Building A +160/+49m 12 2023 Under Construction Planned main building for redeveloped Marine Drive Apartments.

Tallest cancelled and stale proposals This section denotes proposals that are now cancelled or the proposal has sat longer than 2 years.

NameHeightfeet / mFloorsYear ProposedStatus Notes Unity Tower at Cobblestone Place +656/+200m 55 2020 Stale proposal Proposed tongue-in-cheek by owner at the time of Cobblestone buildings. Nothing ever materialized from this plan. Buffalo City Tower 600 / 183 40 2006 cancelled This project was cancelled due to the financial woes of the developer, BSC Group Apartments at Queen City Landing 324 / 99 20 2016 cancelled Proposed height later reduced from 23 to 20 stories. Project was repeatedly stymied by litigation due to environmental concerns, "suspended indefinitely" in 2020 due to the developer's inability to secure financing from the city, and definitively cancelled in 2021 when the property was put up for sale. 33 Gates Circle 297 / 85 23 2006 cancelled Project cancelled due to the 2008 financial crisis. In 2018, the developer proposed a series of three-story, 12-unit townhouses for the site. Seneca Buffalo Creek Casino Hotel Tower 220 / 67 22 2010 cancelled The Seneca Buffalo Creek Casino was completed in 2013 without the hotel tower Adelphia Tower 220 / 67 15 2004 cancelled The project size and scope was altered several times (40 floors, 38 floors, 22 floors and finally 15 floors) before being cancelled The Carlo 186 / 57 (est) 14 2012 Stale Proposal

Tallest destroyed buildings This lists buildings in the city of Buffalo that once existed and rose at least 150 ft (46 m) but have since been destroyed.