De Ayala is a surname. Notable people with the surname include:
Adelardo López de Ayala y Herrera (1828–1879), Spanish writer and politician Enrique Zóbel de Ayala (1877–1943), Spanish-born Filipino industrialist, philanthropist, and a leader of the Philippine Falange political party Felipe Guaman Poma de Ayala (c. 1550–after 1616), indigenous Peruvian chronicler during the Spanish conquest Fernando Zobel de Ayala (born 1960), Filipino businessman, brother of Jaime Augusto Zobel de Ayala Jaime Augusto Zobel de Ayala (born 1959), current CEO of Ayala Corporation, son of Jaime Zobel de Ayala Jaime Zobel de Ayala (born 1934), Filipino businessman and photographer, founder of the Ayala Corporation Josefa de Óbidos (c.1630–1684), Spanish-born Portuguese painter who signed her work as Josefa de Ayala or Josefa em Óbidos Juan de Ayala (1745–1797), Spanish naval officer and explorer Pero López de Ayala (1332–1407), Castilian statesman, historian, poet, chronicler, chancellor, and courtier Pedro de Ayala (died 1513), Spanish diplomat in England and Scotland Pero López de Ayala (1332–1407), Castilian chronicler, diplomat, and poet Pilar López de Ayala (born 1978), Spanish film actress Ramón Pérez de Ayala (circa 1880–1962), Spanish writer
See also Ayala (surname)