Horcasitas is a surname. Notable people with the surname include:
Juan Francisco de Güemes y Horcasitas, 1st Count of Revillagigedo (1681–1766), Spanish general, governor of Havana, captain general of Cuba, and viceroy of New Spain Juan Molinar Horcasitas (1955–2015), Mexican academic, civil servant and politician Juan Vicente de Güemes Padilla Horcasitas y Aguayo, 2nd Count of Revillagigedo (1740–1799), Spanish military officer and viceroy of New Spain
See also San Miguel de Horcasitas Municipality, Sonora, Mexico San Miguel de Horcasitas, a town in the municipality